Protein Details: Aquaporin-12

Protein ID

ICDB_Pro_1234

Protein Name

Aquaporin-12

Gene Name

Aqp12

Organism

Mus musculus (Mouse)

Length

290 amino acids

AlphaFoldDB

AF-Q8CHJ2-F1-model_v4.pdb

Function

Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.

Sequence

MASLNVSLCFFFATCAICEVARRASKALLPAGTYASFARGAVGAAQLAACCLEMRVLVELGPWAGGFGPDLLLTLVFLLFLVHGVTFDGASANPTVALQEFLMVEASLPNTLLKLSAQVLGAQAACALTQRCWAWELSELHLLQSLMAAHCSSTLRTSVLQGMLVEGACTFFFHLSLLHLQHSLLVYRVPALALLVTLMAYTAGPYTSAFFNPALAASVTFHCPGNTLLEYAHVYCLGPVAGMILAVLLHQGHLPRLFQRNLFYRQKSKYRTPRGKLSPGSVDAKMHKGE

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Restricted to pancreatic acinar cells

DOI ID

10.1016/j.bbrc.2005.03.046; 10.1101/gr.2596504; 10.1016/j.cell.2010.12.001

RefSeq

NP_808255.1